Free ACRP CPI Practice Questions
Original questions with explanations
These original ACRP CPI practice questions are educational examples designed to exercise reasoning. They are not recalled exam items and do not imply access to live or confidential test content.
Question 1
A protocol deviation may affect participant safety. What is the investigator’s priority?
- A. Hide the deviation
- B. Protect the participant, document the event, and report as required
- C. Change the source record
- D. Wait until study closeout
Answer and explanation
B. Protect the participant, document the event, and report as required Participant protection and timely documentation and reporting take priority.
Question 2
Which responsibility remains with the principal investigator after delegating a task?
- A. No oversight is required
- B. Appropriate supervision and assurance that delegated staff are qualified
- C. Only payroll approval
- D. Vendor marketing
Answer and explanation
B. Appropriate supervision and assurance that delegated staff are qualified Delegation does not remove the investigator’s responsibility for qualified staff and adequate oversight.
Question 3
A potential participant does not understand a key study risk. What should happen?
- A. Obtain the signature anyway
- B. Continue the consent discussion until understanding is adequate or do not enroll
- C. Ask another participant to decide
- D. Omit the risk
Answer and explanation
B. Continue the consent discussion until understanding is adequate or do not enroll Informed consent requires meaningful comprehension, not a signature alone.
Question 4
What is the best response to repeated data discrepancies at a site?
- A. Delete queries
- B. Analyze the cause, correct records appropriately, retrain if needed, and monitor effectiveness
- C. Backdate entries
- D. Ignore the pattern
Answer and explanation
B. Analyze the cause, correct records appropriately, retrain if needed, and monitor effectiveness Root-cause correction and follow-up protect data integrity and study quality.
Question 5
Which reference should guide a candidate testing after July 15, 2026?
- A. ICH E6(R2) only
- B. The ACRP outline and ICH E6(R3) references identified by ACRP
- C. Country-specific law alone
- D. Recalled live items
Answer and explanation
B. The ACRP outline and ICH E6(R3) references identified by ACRP ACRP identified ICH E6(R3) as the governing reference beginning July 15, 2026.
How to Review Your Results
For every missed item, name the tested concept, explain why the correct option is best, and identify the clue that rules out each distractor. Then review the corresponding official content domain.