Free ACRP-CP Practice Questions
Original questions with explanations
These original ACRP-CP practice questions are educational examples designed to exercise reasoning. They are not recalled exam items and do not imply access to live or confidential test content.
Question 1
Which principle is central to every clinical research role?
- A. Participant rights, safety, and well-being take priority
- B. Enrollment always outweighs protocol compliance
- C. Undocumented changes are acceptable
- D. Only the sponsor manages quality
Answer and explanation
A. Participant rights, safety, and well-being take priority Good clinical practice places participant rights, safety, and well-being above scientific and operational interests.
Question 2
A protocol deviation is discovered. What is the appropriate response?
- A. Hide it
- B. Document, assess impact, report as required, and address the cause
- C. Change the source record
- D. Wait until study closeout
Answer and explanation
B. Document, assess impact, report as required, and address the cause Deviations require transparent documentation, impact assessment, required reporting, and corrective action.
Question 3
What makes an electronic record attributable?
- A. It identifies who performed the action and when
- B. It can be overwritten without history
- C. It is stored only on paper
- D. It omits audit trails
Answer and explanation
A. It identifies who performed the action and when Attributability connects a record or change to the responsible individual and time.
Question 4
Which action best supports risk-proportionate trial management?
- A. Focus controls on critical data and processes
- B. Apply identical effort to every low-risk detail
- C. Avoid documenting risks
- D. Eliminate oversight
Answer and explanation
A. Focus controls on critical data and processes Risk-proportionate management directs controls toward factors that matter most to participants and reliable results.
Question 5
A consent form is revised with important new risk information. What should guide implementation?
- A. Personal preference
- B. Approved procedures for ethics review, communication, and re-consent when applicable
- C. Marketing timelines
- D. The oldest version on file
Answer and explanation
B. Approved procedures for ethics review, communication, and re-consent when applicable Important new information must follow the approved review and participant-communication process.
How to Review Your Results
For every missed item, name the tested concept, explain why the correct option is best, and identify the clue that rules out each distractor. Then review the corresponding official content domain.